N‐Propanoylmannosamine interferes with O‐GlcNAc modification of the tyrosine 3‐monooxygenase and stimulates dopamine secretion

@article{Bork2008NPropanoylmannosamineIW,
  title={N‐Propanoylmannosamine interferes with O‐GlcNAc modification of the tyrosine 3‐monooxygenase and stimulates dopamine secretion},
  author={Kaya Bork and C. Kannicht and S. Noehring and W. Reutter and Wenke Weidemann and G. Hart and R. Horstkorte},
  journal={Journal of Neuroscience Research},
  year={2008},
  volume={86}
}
The most consistent neurochemical abnormality in Parkinson's disease is degeneration of dopaminergic neurons in the substantia nigra, leading to a reduction of striatal dopamine levels. The rate‐limiting step in the biosynthesis of dopamine, noradrenalin, and adrenalin is catalyzed by tyrosine 3‐monooxygenase (=tyrosine hydroxylase), which catalyzes the formation of L‐DOPA. In earlier studies, we demonstrated that the novel synthetic sialic acid precursor N‐propanoylmannosamine is a potent… Expand
The emerging link between O-GlcNAcylation and neurological disorders
Nutrient regulation of signaling and transcription
  • G. Hart
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 2019

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