N‐ARALKYL SUBSTITUTION INCREASES THE AFFINITY OF ADRENERGIC DRUGS FOR THE α‐ADRENOCEPTOR IN RAT LIVER

@article{Aggerbeck1979NARALKYLSI,
  title={N‐ARALKYL SUBSTITUTION INCREASES THE AFFINITY OF ADRENERGIC DRUGS FOR THE $\alpha$‐ADRENOCEPTOR IN RAT LIVER},
  author={Martine Aggerbeck and Georges Guellaen and Jacques Hanoune},
  journal={British Journal of Pharmacology},
  year={1979},
  volume={65}
}
1 The α‐adrenoceptor of rat liver plasma membranes was studied by use of the specificα‐antagonist [3H]‐dihydroergocryptine ([3H]‐DHEC). Catecholamines and adrenergic compounds displayed an order of affinity that is typical of anα‐receptor. Nevertheless, protokylol, a potent β‐adrenoceptor agonist, exhibited a higher affinity than that of adrenaline forα‐sites. This result might be due to its bulky substituent on the amino group. 2 Further displacement experiments between [3H]‐DHEC and four… Expand
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