N,N-dimethylglycine differentially modulates psychotomimetic and antidepressant-like effects of ketamine in mice

@article{Lin2016NNdimethylglycineDM,
  title={N,N-dimethylglycine differentially modulates psychotomimetic and antidepressant-like effects of ketamine in mice},
  author={Jen-Cheng Lin and Ming-Huan Chan and Meiyi Lee and Yi-Chyan Chen and Hwei-Hsien Chen},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2016},
  volume={71},
  pages={7-13}
}
  • Jen-Cheng Lin, Ming-Huan Chan, +2 authors Hwei-Hsien Chen
  • Published 2016
  • Medicine, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • Ketamine, a dissociative anesthetic, produces rapid and sustained antidepressant effects at subanesthtic doses. However, it still inevitably induces psychotomimetic side effects. N,N-dimethylglycine (DMG) is a derivative of the amino acid glycine and is used as a dietary supplement. Recently, DMG has been found acting at glycine binding site of the N-methyl-d-aspartate receptor (NMDAR). As blockade of NMDARs is one of the main mechanisms responsible for the action of ketamine on central nervous… CONTINUE READING

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