N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain

  title={N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain},
  author={{\'I}risz Szab{\'o} and Vikt{\'o}ria {\'E}. Varga and Szabolcs Dvor{\'a}csk{\'o} and Attila E. Farkas and T{\'i}mea K{\"o}rm{\"o}czi and R{\'o}bert Berkecz and Szilvia Kecsk{\'e}s and {\'A}kos Menyh{\'a}rt and Rita Frank and D{\'o}ra Hantosi and Nicholas V Cozzi and Ede Frecska and Csaba T{\"o}mb{\"o}ly and Istvan A Krizbai and Ferenc Bari and Eszter Farkas},
Dimethyltryptamine (DMT), an endogenous ligand of sigma-1 receptors (Sig-1Rs), acts against systemic hypoxia, but whether DMT may prevent cerebral ischemic injury is unexplored. Here global forebrain ischemia was created in anesthetized rats and aggravated with the induction of spreading depolarizations (SDs) and subsequent short hypoxia before reperfusion. Drugs (DMT, the selective Sig-1R agonist PRE-084, the Sig-1R antagonist NE-100, or the serotonin receptor antagonist asenapine) were… Expand

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