N,N-Diethyl Phenylacetamide (DEPA): A Safe and Effective Repellent for Personal Protection Against Hematophagous Arthropods

  title={N,N-Diethyl Phenylacetamide (DEPA): A Safe and Effective Repellent for Personal Protection Against Hematophagous Arthropods},
  author={Muthuswami Kalyanasundaram and Nisha Mathew},
  booktitle={Journal of medical entomology},
Abstract Repellents play an important role in protecting humans from the bites of insect pests. An effective and safe repellent will be useful in reducing human-vector contact and thereby help in the interruption of vector borne disease transmission. Because of the unavailability of m-toluic acid in India for the manufacture of N,N-diethyl m-toluamide (DEET), there is a need to develop an alternate effective and safe insect repellent. In total, 120 substituted amides were synthesized and tested… 
Laboratory Study on the Repellent Bioefficacy of Diethyl Phenyl Acetamide (DEPA) against Aedes (Stegomyia) aegypti (Linnaeus)
Evaluating the repellency effect of a repellent cream containing 20% w/v diethyl phenyl acetamide (DEPA) against Aedes aegypti found there was statistically no significant difference between the repeller activity of both repellents (p>0.05), indicating the repelling cream of DEPA was as effective as DEET.
Efficacy of Advanced Odomos repellent cream (N, N-diethyl-benzamide) against mosquito vectors
The laboratory and field trials indicate that for longer protection against Anopheles mosquitoes 10 mg/cm2 will be appropriate and in case of Ae.
Repellent activity of N, N-diethylphenylacetamide (DEPA) with essential oils against Aedes aegypti, vector of dengue and chikungunya
It is found that protection time of essential oils when tested individually was found to be upto 4hrs, and DEPA 20% alone was more effective than that of combination with essential oils and essential oils alone.
The fabrication and assessment of mosquito repellent cream for outdoor protection
The study emphasizes the mosquito repellent activity of EO-MRC, which could be an effective, eco-friendly, and safer alternative to the existing synthetic repellents for personal protection against mosquitoes during field conditions.
A Novel Ex Vivo Bioassay Suggests DEET is an Effective Repellent of Rhipicephalus Sanguineus1
It is demonstrated that concentrations of DEET lower than those in commercial repellents may provide sufficient repellency when potential tick exposure occurs shortly after application.
Effects of Preexposure to DEET on the Downstream Blood-Feeding Behaviors of Aedes aegypti (Diptera: Culicidae) Mosquitoes
Abstract Mosquito behavior is heavily influenced by the chemical molecules in the environment. This knowledge can be used to modify insect behaviors; particularly to reduce vector–host contact as a
Behavioral Responses and Bioefficacy of Some Aromatic Amides Against Aedes aegypti
A series of substituted aromatic amides by varying the chain length, substitution of methyl, methoxy, chloro, and fluoro groups at ortho-, meta-, and para-positions of the phenyl ring of N,N-diethyl-2-phenylacetamide were synthesized, showing deterrent activity against Aedes aegypti (L.) mosquitoes.
Efficacy study of indigenously developed mosquito repellent BiteFree & its comparison with commercially available mosquito repellent
  • N. Hai, Fazal Haq
  • Medicine
    2018 15th International Bhurban Conference on Applied Sciences and Technology (IBCAST)
  • 2018
Bite-Free a indigenously developed mosquito repellent cream, in which active ingredient is DEET (25% w/w) was evaluated for its efficacy under controlled laboratory conditions, using arm in cage method, based on a WHO standardized procedures.


Laboratory & field evaluation of controlled release formulation of the insect repellents N,N-diethyl-m-toluamide (DEET) & N,N-diethyl phenylacetamide (DEPA) against mosquito vectors.
In laboratory and field tests, the lotions formulations of both repellents were found to give a higher protection compared to alcohol solution and the lotion formulations of DEET and DEPA were finding to be equally effective.
Insect repellent formulations of N,N-diethyl-m-toluamide (deet) in a liposphere system: efficacy and skin uptake.
Novel formulations for a deet in liposphere microdispersion in the form of lotion were prepared from natural solid triglycerides and phospholipids dispersed in buffer solution and showed effective as a repellent against the common aggressive biting mosquitoes.
Development & evaluation of controlled release formulations of DEPA, an insect repellent.
Three controlled release formulations of the insect repellent DEPA (N, N-Diethyl phenylacetamide), Depa-A, Depa-B and Depa-C have been developed and tested on human subjects against Aedes aegypti
N,N-diethylphenylacetamide, an insect repellent: absence of mutagenic response in the in vitro Ames test and in vivo mouse micronucleus test.
  • G. P. Meshram, K. M. Rao
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1988
Laboratory tests of repellents against Lutzomyia longipalpis (Diptera: Psychodidae).
Comparative sensitivity of this sand fly species to repellents appears to be greater than that of certain mosquito, flea, tick, and reduviid bug species.
Relative potency of DEPA as a repellent against the sandfly Phlebotomus papatasi
Both DEPA and DEET were found to be more effective than DMP, but there was no significant difference between the efficacy of DEPA or DEET.
Acute oral toxicity of insect repellent N,N-diethylphenylacetamide in mice, rats and rabbits and protective effect of sodium pentobarbital.
Administration of SPB after the same dose of DEPA reduced the degree of acidosis and raised PCO2, and increased the O2 content and per cent O2 saturation to near normal status, and may be a crucial factor in protection of rats from DEPA poisoning.
Relative effectiveness of chemical repellents against Phlebotomus papatasi (Scopoli).
In a comparative evaluation of 9 chemicals as repellents against Phlebotomus papatasi , chloro-diethylbenzamide was found to afford longest protection. Ethoxy-diethylbenzamide, diethyltoluamide,