N,N,N',N'-tetrakis(2-pyridylmethyl)-ethylenediamine improves myocardial protection against ischemia by modulation of intracellular Ca2+ homeostasis.

@article{Shmist2005NNNNtetrakis2pyridylmethylethylened,
  title={N,N,N',N'-tetrakis(2-pyridylmethyl)-ethylenediamine improves myocardial protection against ischemia by modulation of intracellular Ca2+ homeostasis.},
  author={Yelena A. Shmist and Roman Kamburg and Gal Ophir and A. V. Kozak and Vladimir Shneyvays and Yori J Appelbaum and Asher Shainberg},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2005},
  volume={313 3},
  pages={1046-57}
}
N,N,N',N'-Tetrakis(2-pyridylmethyl)-ethylenediamine (TPEN), a transition-metal chelator, was recently found to protect against myocardial ischemia-reperfusion injury. The goals of this study were to investigate the in vivo antiarrhythmic and antifibrillatory potential of TPEN in rats and guinea pigs and to study the in vitro effects of TPEN on calcium homeostasis in cultured newborn rat cardiac cells in normoxia and hypoxia. We demonstrated on an in vivo rat model of ischemia-reperfusion that… CONTINUE READING