N,N'-ethylene-di-L-cysteine (EC) complexes of Ga(III) and In(III): molecular modeling, thermodynamic stability and in vivo studies.

@article{Anderson1995NNethylenediLcysteineC,
  title={N,N'-ethylene-di-L-cysteine (EC) complexes of Ga(III) and In(III): molecular modeling, thermodynamic stability and in vivo studies.},
  author={Carolyn Jane Anderson and Christy S. John and You Jun Li and Robert D. Hancock and Timothy J. McCarthy and Arthur E. Martell and Michael J. Welch},
  journal={Nuclear medicine and biology},
  year={1995},
  volume={22 2},
  pages={165-73}
}
There are several reports in the literature on the evaluation of chelates containing two nitrogens and two sulfurs (N2S2) as four coordinate ligands (in solution) for gallium and indium radiopharmaceuticals. No thermodynamic stability constants of these ligands were reported, and the stability of these complexes in vivo has been questioned. L,L-Ethylenedicysteine (EC) is a N2S2 ligand that also contains two carboxylic acid moieties for complexation of Ga(III) and In(III) in a hexacoordinate… CONTINUE READING