Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells.

@article{Flach2010Mzb1PR,
  title={Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells.},
  author={Henrik Flach and Marc Rosenbaum and Marlena Duchniewicz and Sola L Kim and Shenyuan L. Zhang and Michael D Cahalan and Gerhard Mittler and Rudolf Grosschedl},
  journal={Immunity},
  year={2010},
  volume={33 5},
  pages={723-35}
}
Marginal zone (MZ) B cells of the spleen and B1 cells, termed innate-like B cells, differ from follicular B cells by their attenuated Ca(2+) mobilization, fast antibody secretion, and increased cell adhesion. We identified and characterized Mzb1 as an endoplasmic reticulum-localized and B cell-specific protein that was most abundantly expressed in MZ B and B1 cells. Knockdown of Mzb1 in MZ B cells increased Ca(2+) mobilization and nuclear NFAT transcription factor localization, but reduced… CONTINUE READING
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