Myxothiazol, a new inhibitor of the cytochrome b-c1 segment of th respiratory chain.

@article{Thierbach1981MyxothiazolAN,
  title={Myxothiazol, a new inhibitor of the cytochrome b-c1 segment of th respiratory chain.},
  author={Georg Thierbach and H. Graf von Reichenbach},
  journal={Biochimica et biophysica acta},
  year={1981},
  volume={638 2},
  pages={
          282-9
        }
}
Myxothiazol inhibited oxygen consumption of beef heart mitochondria in the presence and absence of 2,4-dinitrophenol, as well as NADH oxidation by submitochondrial particles. The doses required for 50% inhibition were 0.58 mol myxothiazol/mol cytochrome b for oxygen consumption of beef heart mitochondria, and 0.45 mol/mol cytochrome b for NADH oxidation by submitochondrial particles. Difference spectra with beef heart mitochondria and with cell suspensions of Saccharomyces cerevisiae revealed… CONTINUE READING

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