Myxoma Virus Induces Type I Interferon Production in Murine Plasmacytoid Dendritic Cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-Dependent Pathway

@article{Dai2011MyxomaVI,
  title={Myxoma Virus Induces Type I Interferon Production in Murine Plasmacytoid Dendritic Cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-Dependent Pathway},
  author={P. Dai and H. Cao and T. Merghoub and F. Avogadri and Weiyi Wang and Tanvi N. Parikh and Chee-Mun Fang and P. Pitha and K. Fitzgerald and Masmudur M. Rahman and G. McFadden and Xiaoyu Hu and A. Houghton and S. Shuman and Liang Deng},
  journal={Journal of Virology},
  year={2011},
  volume={85},
  pages={10814 - 10825}
}
ABSTRACT Poxviruses are large DNA viruses that replicate in the cytoplasm of infected cells. Myxoma virus is a rabbit poxvirus that belongs to the Leporipoxvirus genus. It causes a lethal disease called myxomatosis in European rabbits but cannot sustain any detectable infection in nonlagomorphs. Vaccinia virus is a prototypal orthopoxvirus that was used as a vaccine to eradicate smallpox. Myxoma virus is nonpathogenic in mice, whereas systemic infection with vaccinia virus can be lethal even in… Expand
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