Myths and misconceptions concerning contrast media-induced anaphylaxis: a narrative review

@article{Bhm2017MythsAM,
  title={Myths and misconceptions concerning contrast media-induced anaphylaxis: a narrative review},
  author={Ingrid B{\"o}hm and John N. Morelli and Knud Nairz and Patricia Silva Hasembank Keller and Johannes T. Heverhagen},
  journal={Postgraduate Medicine},
  year={2017},
  volume={129},
  pages={259 - 266}
}
ABSTRACT Contrast-enhanced radiological examinations are an increasingly important diagnostic tool in modern medicine. All approved and available contrast media (iodinated and gadolinium-based) are safe compounds that are well-tolerated by most patients. However, a small percentage of patients exhibit contrast medium-induced adverse drug reactions that are dose-dependent and predictable (type A) or an even smaller cohort experience so-called type B (dose-independent, non-predictable). To… 
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32 Citations

Shelling the myth: allergies to Iodine containing substances and risk of reaction to Iodinated contrast media
TLDR
There is a lack of understanding amongst local junior medical staff regarding administration of iodinated contrast media to patients with a history of allergy to iodinated substances, which may potentiate the unnecessary usage of pre-medication and ordering of non-contrast scans in the setting of a gold-standard enhanced scan.
Premedication for Iodinated Contrast Media Induced Immediate Hypersensitivity Reactions
TLDR
Although premedication reduces reoccurrence of mild iHR, it is not always efficacious and should be balanced against side effects, a high NNT and an uncertain efficacy physicians should not blindly rely on.
Pharmacologic and non-pharmacologic interventions to prevent hypersensitivity reactions of non-ionic iodinated contrast media: a systematic review protocol
TLDR
The preventive effects of pharmacologic and non-pharmacologic interventions and predictors of acute, hypersensitivity reactions of non-ionic iodinated contrast media are reviewed systematically to reduce the risk of severe reactions.
Delayed hypersensitivity reaction after oral intake of non-ionic iodinated contrast medium
TLDR
A case who acquired a delayed hypersensitivity reaction following the oral intake of a non-ionic iodinated CM is described.
Clinical impact of allergy and pre-medication in CT studies with low-osmolality intravenous iodinated contrast media.
The Use of Contrast Agents in Interventional Pain Procedures: A Multispecialty and Multisociety Practice Advisory on Nephrogenic Systemic Fibrosis, Gadolinium Deposition in the Brain, Encephalopathy After Unintentional Intrathecal Gadolinium Injection, and Hypersensitivity Reactions
TLDR
The advisory provides recommendations on the selection of a specific gadolinium-based contrast agent in patients with renal insufficiency, those who had multiple gadolinia-enhanced magnetic resonance imaging examinations, and in cases of paraspinal injections.
Risks of contrast media applied via the gastrointestinal route.
Cross-Reactivity and Polyvalent Reactivity in Patients with Iodinated Contrast Medium Allergy: How to Use the Terms Correctly
TLDR
The goal of this letter is to explain these terms, and thereby to enhance knowledge and clinical progress, by providing a detailed in-depth explanation of these terms.
Radiologic Contrast Reactions and Transfusion Reactions: Recognition, Differentiation, and Treatment
Iodinated Contrast Media Allergy in Patients Hospitalized for Investigation of Chest Pain.
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