Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit

@article{Nakajima2008Myt1PK,
  title={Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit},
  author={Hiroyuki Nakajima and Shigenobu Yonemura and Masayuki Murata and Nobuhiro Nakamura and Helen Piwnica-Worms and Eisuke Nishida},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={181},
  pages={89 - 103}
}
Myt1 was originally identified as an inhibitory kinase for Cdc2 (Cdk1), the master engine of mitosis, and has been thought to function, together with Wee1, as a negative regulator of mitotic entry. In this study, we report an unexpected finding that Myt1 is essential for Golgi and endoplasmic reticulum (ER) assembly during telophase in mammalian cells. Our analyses reveal that both cyclin B1 and cyclin B2 serve as targets of Myt1 for proper Golgi and ER assembly to occur. Thus, our results show… CONTINUE READING
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Mitotic Golgi partitioning is driven by the membranefi ssioning protein CtBP 3 / BARS

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