Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth.

@article{Loughran2005MystiqueIA,
  title={Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth.},
  author={Gary Loughran and Nollaig C. Healy and Patrick A. Kiely and Merei Huigsloot and Nancy L. Kedersha and Rosemary O'Connor},
  journal={Molecular biology of the cell},
  year={2005},
  volume={16 4},
  pages={
          1811-22
        }
}
By comparing differential gene expression in the insulin-like growth factor (IGF)-IR null cell fibroblast cell line (R- cells) with cells overexpressing the IGF-IR (R+ cells), we identified the Mystique gene expressed as alternatively spliced variants. The human homologue of Mystique is located on chromosome 8p21.2 and encodes a PDZ LIM domain protein (PDLIM2). GFP-Mystique was colocalized at cytoskeleton focal contacts with alpha-actinin and beta1-integrin. Only one isoform of endogenous human… CONTINUE READING