Mystery of the poisoned expedition

  title={Mystery of the poisoned expedition},
  author={John W. Earl and Barry V. McCleary},
The Burke and Wills expedition through the interior of Australia in the nineteenth century ended in calamity. But the cause of death was more pernicious than anyone at the time had imagined: beriberi due to thiaminase poisoning. 
A nardoo processing grinding stone from a rockshelter in the Pilbara, Western Australia
Abstract Nardoo (scientific name Marsilea spp.) is a small freshwater fern, common across semi-arid and arid Australia. While reported as an important starchy food, albeit requiring complexExpand
Thiamin is decomposed due to Anaphe spp. entomophagy in seasonal ataxia patients in Nigeria.
The results indicate the necessity of thorough heat treatment for the detoxification of the African silkworm, making the worm a safe source of high-quality protein. Expand
Thiaminase activity of crucian carp Carassius carassius injected with a bacterial fish pathogen, Aeromonas salmonicida subsp. salmonicida.
The amount of thiaminase I enzyme appeared to be elevated in the whole blood of injected fish in the absence of natural cosubstrate(s), which suggests that in addition to the enzyme, some cosubstrates of fish or pathogen origin play a regulatory role in the so-farunknown physiological significance of thienine deficiency in animals. Expand
Grinding grounds: function and distribution of grinding stones from an open site in the Pilbara, western Australia
Abstract Grinding stones are sometimes found as isolated artefacts but more commonly as minor components of archaeological sites, defined in site registers as lithic scatters or lithic concentrationsExpand
Structural biology of enzymes of the thiamin biosynthesis pathway.
Structural and mechanistic studies on thiamin biosynthetic enzymes have played a key role in increasing the understanding ofThiamin pyrophosphate biosynthesis and have revealed unexpected evolutionary ties. Expand
Competition for vitamin B1 (thiamin) structures numerous ecological interactions
Overall, thiamin biochemistry is portrayed as the foundation for molecularly mediated ecological interactions that influence survival and abundance of a vast array of organisms. Expand
The structural and biochemical foundations of thiamin biosynthesis.
Two thiamin degrading enzymes have been characterized and one of which is linked to a novel salvage pathway that can be salvaged through several routes, and the thiazole and pyrimidine moieties are synthesized in separate branches of the pathway. Expand
An assay for thiaminase I in complex biological samples.
An alternative method for measuring thiaminase I activity in complex samples is described, which is simple and sensitive, and it requires only readily available chemicals and a visible region spectrophotometer. Expand
Structure of a eukaryotic thiaminase I
The crystal structures in both apo form and bound to 3-deazathiamin, a noncleavable thiamin analog and inhibitor of the enzyme, define the mode ofThiamin binding to this class of Thiaminases and indicate the residues important for catalysis. Expand
Pathophysiology, prevention, and treatment of beriberi after gastric surgery
Abstract Beriberi is a nutritional complication of gastric surgery, caused by deficiency of vitamin B1, or thiamine. Thiamine deficiency leads to impaired glucose metabolism, decreased delivery ofExpand


The purification and properties of a thiaminase I enzyme from nardoo (Marsilea drummondii)
Abstract Fronds of the fern nardoo (Marsilea drummondii) contain a thiaminase I enzyme at very high levels of activity. Highest levels of enzyme activity were found in vigorously growing plantExpand