Mysteries of muscle contraction.

  title={Mysteries of muscle contraction.},
  author={Walter Herzog and Timothy R. Leonard and Venus Joumaa and Ashi Mehta},
  journal={Journal of applied biomechanics},
  volume={24 1},
According to the cross-bridge theory, the steady-state isometric force of a muscle is given by the amount of actin-myosin filament overlap. However, it has been known for more than half a century that steady-state forces depend crucially on contractile history. Here, we examine history-dependent steady-state force production in view of the cross-bridge theory, available experimental evidence, and existing explanations for this phenomenon. This is done on various structural levels, ranging from… CONTINUE READING

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