Myristoylated alanine-rich C-kinase substrate as a prognostic biomarker in human primary lung squamous cell carcinoma.

@article{Hanada2013MyristoylatedAC,
  title={Myristoylated alanine-rich C-kinase substrate as a prognostic biomarker in human primary lung squamous cell carcinoma.},
  author={Shoji Hanada and Anna Kakehashi and Noritoshi Nishiyama and Min Wei and Shotaro Yamano and Kyukwang Chung and Hiroaki Komatsu and Hidetoshi Inoue and Shigefumi Suehiro and Hideki Wanibuchi},
  journal={Cancer biomarkers : section A of Disease markers},
  year={2013},
  volume={13 4},
  pages={289-98}
}
To identify novel biomarkers for the diagnosis and prognosis of human primary lung squamous cell carcinoma (SCC), we compared the spectrum of proteins expressed in SCC and in the adjacent non-cancer tissue, using QSTAR Elite liquid chromatography with tandem mass spectrometry (LC-MS/MS), coupled with iTRAQ technology. We identified 410 proteins differentially expressed in more than 75% of patients, and validated the expression of candidate target proteins by immunohistochemistry. Based on the… CONTINUE READING

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