Myristoylated alanine-rich C kinase substrate-mediated neurotensin release via protein kinase C-delta downstream of the Rho/ROK pathway.

@article{Li2005MyristoylatedAC,
  title={Myristoylated alanine-rich C kinase substrate-mediated neurotensin release via protein kinase C-delta downstream of the Rho/ROK pathway.},
  author={Jing zhou Li and Kathleen L O'connor and George H. Greeley and PerryJ. Blackshear and Courtney M . Townsend and B Mark Evers},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 9},
  pages={
          8351-7
        }
}
Myristoylated alanine-rich protein kinase C substrate (MARCKS) is a cellular substrate for protein kinase C (PKC). Recently, we have shown that PKC isoforms-alpha and -delta, as well as the Rho/Rho kinase (ROK) pathway, play a role in phorbol 12-myristate 13-acetate (PMA)-mediated secretion of the gut peptide neurotensin (NT) in the BON human endocrine cell line. Here, we demonstrate that activation of MARCKS protein is important for PMA- and bombesin (BBS)-mediated NT secretion in BON cells… CONTINUE READING

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