Myristoleic Acid Promotes Anagen Signaling by Autophagy through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells

  title={Myristoleic Acid Promotes Anagen Signaling by Autophagy through Activating Wnt/$\beta$-Catenin and ERK Pathways in Dermal Papilla Cells},
  author={Youn Kyung Choi and Jung-Il Kang and Jin Won Hyun and Young Sang Koh and Ji-Hoon Kang and Chang-Gu Hyun and Kyung-Sup Yoon and Kwang Sik Lee and Chun Mong Lee and Tae Yang Kim and Eun Sook Yoo and Hee-Kyoung Kang},
  journal={Biomolecules \& Therapeutics},
  pages={211 - 219}
  • Youn Kyung Choi, Jung-Il Kang, +9 authors Hee-Kyoung Kang
  • Published 2021
  • Chemistry, Medicine
  • Biomolecules & Therapeutics
Alopecia is a distressing condition caused by the dysregulation of anagen, catagen, and telogen in the hair cycle. Dermal papilla cells (DPCs) regulate the hair cycle and play important roles in hair growth and regeneration. Myristoleic acid (MA) increases Wnt reporter activity in DPCs. However, the action mechanisms of MA on the stimulation of anagen signaling in DPCs is not known. In this study, we evaluated the effects of MA on anagen-activating signaling pathways in DPCs. MA significantly… Expand

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