Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf.

@article{Jung2010MyricetinSU,
  title={Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf.},
  author={Sung Keun Jung and Ki Won Lee and Ho Young Kim and Mi Hyun Oh and Sanguine Byun and Sung Hwan Lim and Yong-Seok Heo and Nam Joo Kang and Ann M. Bode and Zigang Dong and Hyong Joo Lee},
  journal={Biochemical pharmacology},
  year={2010},
  volume={79 10},
  pages={
          1455-61
        }
}
Chronic exposure to solar ultraviolet (UV) light causes skin photoaging. Many studies have shown that naturally occurring phytochemicals have anti-photoaging effects, but their direct target molecule(s) and mechanism(s) remain unclear. We found that myricetin, a major flavonoid in berries and red wine, inhibited wrinkle formation in mouse skin induced by chronic UVB irradiation (0.18J/cm(2), 3 days/week for 15 weeks). Myricetin treatment reduced UVB-induced epidermal thickening of mouse skin… CONTINUE READING
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