Myotoxic effects of the skeletal muscle-specific immunotoxin, ricin-mAb35, on orbicularis oculi muscle after eyelid injections in rabbits.

@article{Harrison2004MyotoxicEO,
  title={Myotoxic effects of the skeletal muscle-specific immunotoxin, ricin-mAb35, on orbicularis oculi muscle after eyelid injections in rabbits.},
  author={Andrew R. Harrison and Stephanie Skladzien and Stephen P. Christiansen and Linda K. McLoon},
  journal={Ophthalmic plastic and reconstructive surgery},
  year={2004},
  volume={20 4},
  pages={312-6}
}
PURPOSE The authors recently demonstrated that a single injection of the immunotoxin ricin-mAb35 has potent and long-lasting myotoxic effects in extraocular muscles. The myotoxicity of injected ricin-mAb35 was tested in the eyelids of rabbits to determine its potential for use in the treatment of benign essential blepharospasm and other dystonias. METHODS… CONTINUE READING