Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.

@article{Kaliman2005MyotonicDP,
  title={Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.},
  author={Perla Kaliman and Daniele Catalucci and Jason Tsz Hin Lam and Richard Kondo and Jose Gutierrez and Sita Reddy and Manuel Palac{\'i}n and Antonio Zorzano and Kenneth R. Chien and Pilar Ruiz-Lozano},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 9},
  pages={8016-21}
}
Myotonic dystrophy (DM) is caused by a CTG expansion in the 3'-untranslated region of a protein kinase gene (DMPK). Cardiovascular disease is one of the most prevalent causes of death in DM patients. Electrophysiological studies in cardiac muscles from DM patients and from DMPK(-/-) mice suggested that DMPK is critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity. However, there are no data regarding the molecular signaling pathways… CONTINUE READING