Myotonic dystrophy: the correlation of (CTG) repeat length in leucocytes with age at onset is significant only for patients with small expansions.

@article{Hamshere1999MyotonicDT,
  title={Myotonic dystrophy: the correlation of (CTG) repeat length in leucocytes with age at onset is significant only for patients with small expansions.},
  author={Marion G. Hamshere and Heidi Harley and Peter Harper and J. David Brook and John F. Y. Brookfield},
  journal={Journal of medical genetics},
  year={1999},
  volume={36 1},
  pages={59-61}
}
Myotonic dystrophy (DM) was the first of a group of diseases to be identified for which the genetic basis is the expansion of a triplet repeat. Myotonic dystrophy also exhibits anticipation, in which the disease worsens through successive generations. These two features have led many groups to analyse whether a significant negative correlation between triplet repeat length and severity of disease exists. However, the recent molecular finding that two distinct subsets of classically affected DM… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

References

Publications referenced by this paper.
Showing 1-7 of 7 references

Similar Papers

Loading similar papers…