Myostatin levels in skeletal muscle of hibernating ground squirrels.

  title={Myostatin levels in skeletal muscle of hibernating ground squirrels.},
  author={Naomi E. Brooks and Kathryn Helen Myburgh and Kenneth B. Storey},
  journal={The Journal of experimental biology},
  volume={214 Pt 15},
Myostatin, a negative regulator of muscle mass, is elevated during disuse and starvation. Mammalian hibernation presents a unique scenario, where animals are hypocaloric and in torpor, but the extent of muscle protein loss is minimized. We hypothesized that myostatin expression, which is usually increased early in disuse and under hypocaloric conditions, could be suppressed in this unique model. Skeletal muscle was collected from thirteen-lined ground squirrels, Spermophilus tridecemlineatus… CONTINUE READING


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