Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice

@article{Dankbar2015MyostatinIA,
  title={Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice},
  author={Berno Dankbar and Michelle Fennen and Daniela Brunert and Silvia Hayer and Svetlana Frank and C Wehmeyer and Denise Beckmann and Peter Paruzel and Jessica Bertrand and Kurt Redlich and Christina Koers-Wunrau and Athanasios Stratis and Adelheid Korb-Pap and Thomas Pap},
  journal={Nature Medicine},
  year={2015},
  volume={21},
  pages={1085-1090}
}
Myostatin (also known as growth and differentiation factor 8) is a secreted member of the transforming growth factor-β (TGF-β) family that is mainly expressed in skeletal muscle, which is also its primary target tissue. Deletion of the myostatin gene (Mstn) in mice leads to muscle hypertrophy, and animal studies support the concept that myostatin is a negative regulator of muscle growth and regeneration. However, myostatin deficiency also increases bone formation, mainly through loading… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 39 times over the past 90 days. VIEW TWEETS
24 Citations
41 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

References

Publications referenced by this paper.

Similar Papers

Loading similar papers…