Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice

@article{Dankbar2015MyostatinIA,
  title={Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice},
  author={B. Dankbar and M. Fennen and Daniela Brunert and S. Hayer and S. Frank and C. Wehmeyer and D. Beckmann and P. Paruzel and J. Bertrand and K. Redlich and Christina Koers-Wunrau and A. Stratis and A. Korb-Pap and T. Pap},
  journal={Nature Medicine},
  year={2015},
  volume={21},
  pages={1085-1090}
}
Myostatin (also known as growth and differentiation factor 8) is a secreted member of the transforming growth factor-β (TGF-β) family that is mainly expressed in skeletal muscle, which is also its primary target tissue. Deletion of the myostatin gene (Mstn) in mice leads to muscle hypertrophy, and animal studies support the concept that myostatin is a negative regulator of muscle growth and regeneration. However, myostatin deficiency also increases bone formation, mainly through loading… Expand
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