Myostatin inhibits proliferation of human urethral rhabdosphincter satellite cells.

@article{Akita2013MyostatinIP,
  title={Myostatin inhibits proliferation of human urethral rhabdosphincter satellite cells.},
  author={Yasuyuki Akita and Yasuhiro Sumino and Ken-ichi Mori and Takeo Nomura and Fuminori Sato and Hiromitsu Mimata},
  journal={International journal of urology : official journal of the Japanese Urological Association},
  year={2013},
  volume={20 5},
  pages={522-9}
}
OBJECTIVES Myostatin, a member of the transforming growth factor-β superfamily, is a negative regulator of myogenesis in skeletal muscle. We examined the effect of myostatin and myostatin inhibition by an antagonistic agent, follistatin, on growth of human urethral rhabdosphincter satellite cells (muscle stem cells) to develop a new strategy for treatment of stress urinary incontinence. METHODS Rhabdosphincter satellite cells were cultured and selected by magnetic affinity cell sorting using… CONTINUE READING

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