Myostatin inhibits brown adipocyte differentiation via regulation of Smad3-mediated β-catenin stabilization.

@article{Kim2012MyostatinIB,
  title={Myostatin inhibits brown adipocyte differentiation via regulation of Smad3-mediated β-catenin stabilization.},
  author={Won Kon Kim and H Choi and Sung Goo Park and Yong Sang Ko and K H Bae and Sang Chul Lee},
  journal={The international journal of biochemistry & cell biology},
  year={2012},
  volume={44 2},
  pages={327-34}
}
Brown adipocytes play an important role in regulating energy balance, and there is a good correlation between obesity and the amount of brown adipose tissue. Although the molecular mechanism of white adipocyte differentiation has been well characterized, brown adipogenesis has not been studied extensively. Moreover, extracellular factors that regulate brown adipogenic differentiation are not fully understood. Here, we assessed the mechanism of the regulatory action of myostatin in brown… CONTINUE READING