Myostatin gene silenced by RNAi show a zebrafish giant phenotype.

@article{Acosta2005MyostatinGS,
  title={Myostatin gene silenced by RNAi show a zebrafish giant phenotype.},
  author={Jannel Acosta and Yamila Carpio and Ingrid Borroto and Osmany Gonz{\'a}lez and Mario Estrada},
  journal={Journal of biotechnology},
  year={2005},
  volume={119 4},
  pages={324-31}
}
Myostatin is a member of the transforming growth factor-beta (TGF-beta) family that functions as a negative regulator of skeletal muscle development and growth. Recently, it has been reported that the transgenic zebrafish expressing myostatin prodomain exhibited an increased number of fiber in skeletal muscle. Other novel results suggest that myostatin plays a mayor role during myogenesis, apart from inhibition of proliferation as well as differentiation. We have investigated the ability of… CONTINUE READING

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