Corpus ID: 520716

Myostatin expression in age and denervation-induced skeletal muscle atrophy.

@article{Baumann2003MyostatinEI,
  title={Myostatin expression in age and denervation-induced skeletal muscle atrophy.},
  author={A. Baumann and C. Ibebunjo and W. Grasser and V. Paralkar},
  journal={Journal of musculoskeletal \& neuronal interactions},
  year={2003},
  volume={3 1},
  pages={
          8-16
        }
}
Myostatin is hypothesized to regulate skeletal muscle mass and to be a potential target for therapeutic intervention in sarcopenia. To clarify whether myostatin is invariably associated with sarcopenia, this study examined the levels of expression of myostatin mRNA and protein in Sprague Dawley rats during aging- and denervation-induced sarcopenia. The level of myostatin mRNA in the gastrocnemius decreased progressively with age being 9, 34 and 56% lower at 6, 12 and 27 months, respectively… Expand
Expression of myostatin RNA transcript and protein in gastrocnemius muscle of rats after sciatic nerve resection
TLDR
An animal model of peripheral nerve resection was used to examine the time-dependent changes in myostatin mRNA and protein levels in the denervated gastrocnemius muscle of rats after sciatic neurectomy, and a significant negative linear correlation was found between hisostatin abundance and muscle atrophy degree. Expand
Myostatin expression during human muscle hypertrophy and subsequent atrophy: increased myostatin with detraining
Myostatin is a potent negative regulator of skeletal muscle mass, but its role in human skeletal muscle hypertrophy and atrophy is sparsely described. Muscle biopsies were obtained from young maleExpand
Expression pattern of myostatin in gastrocnemius muscle of rats after sciatic nerve crush injury
TLDR
The expression pattern of myostatin in response to a specific type of muscle atrophy is described and raises the possibility of developing hisostatin as a therapeutic target for future clinical applications. Expand
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Time‐dependent expression of myostatin RNA transcript and protein in gastrocnemius muscle of mice after sciatic nerve resection
TLDR
In the early stage of denervation, the levels of myostatin mRNA and protein in the denervated gastrocnemius muscle increased instantly, reaching a peak at day 3 and day 7 after sciatic neurectomy, respectively, when compared with the normal values. Expand
Myostatin and the skeletal muscle atrophy and hypertrophy signaling pathways
TLDR
Outstanding questions about myostatin-mediated regulation of the anabolic and catabolic signaling pathways in skeletal muscle are highlighted and particular emphasis has been placed on the cross- regulation between hisostatin, the growth-promoting path- ways and the proteolytic systems. Expand
Myostatin as a regulator of fiber size
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In skeletal muscle, functional overload in myostatin knockout mice led to reduced growth in muscle mass and fiber size and a blunted switch of muscle fibers metabolic profile to a slower phenotype compared to their wildtype counterpart. Expand
Myostatin and the skeletal muscle atrophy and hypertrophy signaling pathways
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Questions about myostatin-mediated regulation of the anabolic and catabolic signaling pathways in skeletal muscle are highlighted to highlight outstanding questions about the underlying mechanisms only partially understood. Expand
Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle
TLDR
The results suggest that sepsis and glucocorticoids do not upregulate the expression and activity of myostatin in skeletal muscle. Expand
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