Myostatin Inhibition in Muscle, but Not Adipose Tissue, Decreases Fat Mass and Improves Insulin Sensitivity

@article{Guo2009MyostatinII,
  title={Myostatin Inhibition in Muscle, but Not Adipose Tissue, Decreases Fat Mass and Improves Insulin Sensitivity},
  author={Tingqing Guo and William Jou and Tatyana Chanturiya and Jennifer Portas and Oksana Gavrilova and Alexandra C. McPherron},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={61 - 86}
}
Myostatin (Mstn) is a secreted growth factor expressed in skeletal muscle and adipose tissue that negatively regulates skeletal muscle mass. Mstn(-/-) mice have a dramatic increase in muscle mass, reduction in fat mass, and resistance to diet-induced and genetic obesity. To determine how Mstn deletion causes reduced adiposity and resistance to obesity, we analyzed substrate utilization and insulin sensitivity in Mstn(-/-) mice fed a standard chow. Despite reduced lipid oxidation in skeletal… CONTINUE READING
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