Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases.

@article{Tobin2005MyostatinAN,
  title={Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases.},
  author={James Finbarr Tobin and Anthony J. Celeste},
  journal={Current opinion in pharmacology},
  year={2005},
  volume={5 3},
  pages={328-32}
}
Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. The myostatin pathway is conserved and regulates muscle mass in a number of animal species ranging from fish to humans. Inhibition of myostatin using a variety of therapeutic approaches can increase muscle mass in a number of animal models of human disease, including muscular dystrophy. 
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