Myositis autoantibody inhibits histidyl-tRNA synthetase: a model for autoimmunity

  title={Myositis autoantibody inhibits histidyl-tRNA synthetase: a model for autoimmunity},
  author={Michael B. Mathews and Robert M. Bernstein},
In autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus (SLE), autoantibodies are generated against a variety of macromolecules. Myositis is a human autoimmune disease characterized by weakness and wasting of muscle1. In American studies2,3, antibodies directed against soluble cellular constituents were detected by immunodiffusion in about 60% of cases; the commonest of these, found in 25% of patients, was antibody to the Jo-1 antigen. An antibody system referred… CONTINUE READING
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