Myosin motors: missing structures and hidden springs.

  title={Myosin motors: missing structures and hidden springs.},
  author={Anne Houdusse and H Lee Sweeney},
  journal={Current opinion in structural biology},
  volume={11 2},
High-resolution structures of the motor domain of myosin II and lower resolution actin-myosin structures have led to the "swinging lever arm" model for myosin force generation. The available kinetic data are not all easily reconciled with this model and understanding the final details of the myosin motor mechanism must await actin-myosin co-crystals. The observation that myosin can populate multiple states in the absence of actin has nonetheless led to significant insights. The currently known… CONTINUE READING

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