Myosin molecular motor dysfunction in dystrophic mouse diaphragm.

  title={Myosin molecular motor dysfunction in dystrophic mouse diaphragm.},
  author={Catherine Coirault and Francine Lambert and Sylvain Marchand-Adam and Pierre Attal and Denis Chemla and Yves Lecarpentier},
  journal={The American journal of physiology},
  volume={277 6 Pt 1},
Cross-bridge properties and myosin heavy chain (MHC) composition were investigated in isolated diaphragm from 6-mo-old control ( n = 12) and mdx( n = 12) mice. Compared with control, peak tetanic tension fell by 50% in mdx mice ( P < 0.001). The total number of cross bridges per square millimeter (×109), the elementary force per cross bridge, and the peak mechanical efficiency were lower in mdx than in control mice (each P < 0.001). The duration of the cycle and the rate constant for cross… CONTINUE READING