Myosin-like proteins 1 and 2 are not required for silencing or telomere anchoring, but act in the Tel1 pathway of telomere length control.

@article{Hediger2002MyosinlikeP1,
  title={Myosin-like proteins 1 and 2 are not required for silencing or telomere anchoring, but act in the Tel1 pathway of telomere length control.},
  author={Florence Hediger and Karine Dubrana and Susan M. Gasser},
  journal={Journal of structural biology},
  year={2002},
  volume={140 1-3},
  pages={
          79-91
        }
}
  • Florence Hediger, Karine Dubrana, Susan M. Gasser
  • Published in Journal of structural biology 2002
  • Biology, Medicine
  • The positioning of chromosomal domains in interphase nuclei is thought to facilitate transcriptional repression in yeast. It has been reported that two large coiled-coil proteins of the nuclear envelope, myosin-like proteins 1 and 2, play direct roles in anchoring yeast telomeres to the nuclear periphery, thereby creating a subcompartment enriched for Sir proteins. We have created strains containing complete deletions of mlp1 and mlp2 genes, as well as the double null strain, and find no… CONTINUE READING

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