Myosin light chains are not a physiological substrate of AMPK in the control of cell structure changes.

@article{Bultot2009MyosinLC,
  title={Myosin light chains are not a physiological substrate of AMPK in the control of cell structure changes.},
  author={Laurent Bultot and Sandrine Horman and Dietbert Neumann and M. P. Walsh and Louis Hue and Mark H. Rider},
  journal={FEBS letters},
  year={2009},
  volume={583 1},
  pages={25-8}
}
The kinetics of myosin regulatory light chain (MLC) phosphorylation by recombinant AMP-activated protein kinase (AMPK) were compared with commercial AMPK from rat liver and smooth muscle myosin light chain kinase (smMLCK). With identical amounts of activity units, initial rates of phosphorylation of MLC were at least 100-fold less with recombinant AMPK compared to smMLCK, whereas with rat liver AMPK significant phosphorylation was seen. In Madin-Darby Canine Kidney cells, AMPK activation led to… CONTINUE READING
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