Myosin light chain phosphorylation: modulation of basal and agonist-stimulated venular permeability.

@article{Yuan1997MyosinLC,
  title={Myosin light chain phosphorylation: modulation of basal and agonist-stimulated venular permeability.},
  author={Yuan Yuan and Qiaobing Huang and Huakang Wu},
  journal={The American journal of physiology},
  year={1997},
  volume={272 3 Pt 2},
  pages={H1437-43}
}
We have previously demonstrated that agonists increase microvascular permeability through a phospholipase C-nitric oxide synthase-guanylate cyclase cascade. The aim of this study was to further investigate the downstream end of the signaling pathway with a focus on myosin light chain (MLC) phosphorylation. The apparent permeability coefficient to albumin was measured in isolated coronary venules. Under control conditions, the nitric oxide donor sodium nitroprusside, as well as the guanosine 3… CONTINUE READING
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