Myosin light chain kinase transference induces myosin light chain activation and endothelial hyperpermeability.

@article{Tinsley2000MyosinLC,
  title={Myosin light chain kinase transference induces myosin light chain activation and endothelial hyperpermeability.},
  author={John H. Tinsley and Primal de Lanerolle and Emily D. Wilson and Wenbin Ma and Sarah Y. Yuan},
  journal={American journal of physiology. Cell physiology},
  year={2000},
  volume={279 4},
  pages={
          C1285-9
        }
}
The actomyosin complex is the major cytoskeletal component that controls cell contraction. In this study, we investigated the effects of actomyosin interaction on endothelial barrier function and gap formation. Activated myosin light chain kinase (MLCK) protein was transferred into coronary venular endothelial cell (CVEC) monolayers. Uptake of the activated protein resulted in a significant shift in myosin light chain (MLC) from an unphosphorylated to a diphosphorylated form. In addition, MLCK… CONTINUE READING
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