Myosin light chain kinase signaling in endothelial barrier dysfunction.

  title={Myosin light chain kinase signaling in endothelial barrier dysfunction.},
  author={Robert R. Rigor and Qiang Shen and Christopher D. Pivetti and Mack H. Wu and Sarah Y. Yuan},
  journal={Medicinal research reviews},
  volume={33 5},
Microvascular barrier dysfunction is a serious problem that occurs in many inflammatory conditions, including sepsis, trauma, ischemia-reperfusion injury, cardiovascular disease, and diabetes. Barrier dysfunction permits extravasation of serum components into the surrounding tissue, leading to edema formation and organ failure. The basis for microvascular barrier dysfunction is hyperpermeability at endothelial cell-cell junctions. Endothelial hyperpermeability is increased by actomyosin… CONTINUE READING


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