Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice.

@article{He2008MyosinLC,
  title={Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice.},
  author={Wei-qi He and Ya-Jing Peng and Wen-cheng Zhang and Ning Lv and Jing Tang and Chen Chen and Cheng-Hai Zhang and Song Gao and Hua-Qun Chen and Gang Zhi and Robert Feil and Kristine E. Kamm and James T Stull and Xiang Gao and Min-sheng Zhu},
  journal={Gastroenterology},
  year={2008},
  volume={135 2},
  pages={610-20}
}
BACKGROUND & AIMS Smooth muscle is essential for maintaining homeostasis for many body functions and provides adaptive responses to stresses imposed by pathologic disorders. Identified cell signaling networks have defined many potential mechanisms for initiating smooth muscle contraction with or without myosin regulatory light chain (RLC) phosphorylation by myosin light chain kinase (MLCK). We generated tamoxifen-inducible and smooth muscle-specific MLCK knockout (KO) mice and provide direct… CONTINUE READING
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Cytoskeleton 2006;63:375–383

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