Myosin isoenzyme redistribution in chronic heart overload

  title={Myosin isoenzyme redistribution in chronic heart overload},
  author={A. M. Lompr{\'e} and Ketty Schwartz and Anne d'Albis and Gabrielle Lacombe and Nguyen Van Thiem and Bernard Swynghedauw},
Since the first observation by Spann et al.1, it has become clear that in cardiac hypertrophy induced by a mechanical overloading, the velocity of shortening of the cardiac muscle (Vmax) is reduced (see ref. 2 for review). Most authors agree that this mechanical alteration is accompanied by a decrease in the Ca2+-dependent ATPase activity of myosin (see ref. 3 for review). The molecular basis of such changes was unknown because the structural modifications of the myosin molecule were ill… CONTINUE READING

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