Myosin isoenzyme redistribution in chronic heart overload

@article{Lompr1979MyosinIR,
  title={Myosin isoenzyme redistribution in chronic heart overload},
  author={A. M. Lompr{\'e} and Ketty Schwartz and Anne d'Albis and Gabrielle Lacombe and Nguyen Van Thiem and Bernard Swynghedauw},
  journal={Nature},
  year={1979},
  volume={282},
  pages={105-107}
}
Since the first observation by Spann et al.1, it has become clear that in cardiac hypertrophy induced by a mechanical overloading, the velocity of shortening of the cardiac muscle (Vmax) is reduced (see ref. 2 for review). Most authors agree that this mechanical alteration is accompanied by a decrease in the Ca2+-dependent ATPase activity of myosin (see ref. 3 for review). The molecular basis of such changes was unknown because the structural modifications of the myosin molecule were ill… CONTINUE READING

From This Paper

Topics from this paper.
147 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 147 extracted citations

Similar Papers

Loading similar papers…