Myosin heavy chain turnover and glucocorticoid deterrence by exercise in muscle.

  title={Myosin heavy chain turnover and glucocorticoid deterrence by exercise in muscle.},
  author={Susan M Czerwinski and Radovan Zak and Thomas T. Kurowski and M T Falduto and Robert C. Hickson},
  journal={Journal of applied physiology},
  volume={67 6},
This study was undertaken to determine whether regular endurance running, of the type known to attenuate glucocorticoid-induced muscle atrophy, produces a reversal of the glucocorticoid-mediated suppression of myosin heavy chain (MHC) synthesis. Female rats were arbitrarily assigned to one of four groups. There were two sedentary groups that received either a vehicle (1% aqueous carboxymethyl cellulose) or cortisol acetate (100 mg/kg body wt) for 11 consecutive days and two exercise (treadmill… CONTINUE READING


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