Myosin heavy chain gene amplification as a suppressor mutation in Caenorhabditis elegans

Abstract

In the nematode, Caenorhabditis elegans, the body wall muscles contain paramyosin and two different types of myosin heavy chain, MHC A and MHC B. In mutants that do not express MHC B or that express defective paramyosin, muscle structure is disrupted and movement is impaired. Second site mutations in the sup-3 locus partially reverse these defects and are… (More)
DOI: 10.1007/BF00261165

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