Myosin heavy chain and cardiac troponin T damage is associated with impaired myofibrillar ATPase activity contributing to sarcomeric dysfunction in Ca2+-paradox rat hearts

@inproceedings{Kovcs2017MyosinHC,
  title={Myosin heavy chain and cardiac troponin T damage is associated with impaired myofibrillar ATPase activity contributing to sarcomeric dysfunction in Ca2+-paradox rat hearts},
  author={{\'A}rp{\'a}d Kov{\'a}cs and Judit Kal{\'a}sz and Enikő T. P{\'a}sztor and Attila Toth and Zolt{\'a}n Papp and Naranjan S. Dhalla and Judit Barta},
  booktitle={Molecular and Cellular Biochemistry},
  year={2017}
}
This study aimed to explore the potential contribution of myofibrils to contractile dysfunction in Ca2+-paradox hearts. Isolated rat hearts were perfused with Krebs–Henseleit solution (Control), followed by Ca2+-depletion, and then Ca2+-repletion after Ca2+-depletion (Ca2+-paradox) by Langendorff method. During heart perfusion left ventricular developed pressure (LVDP), end-diastolic pressure (LVEDP), rate of pressure development (+ dP/dt), and pressure decay (-dP/dt) were registered. Control… CONTINUE READING
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