Myosin head orientation: a structural determinant for the Frank-Starling relationship.

@article{Farman2011MyosinHO,
  title={Myosin head orientation: a structural determinant for the Frank-Starling relationship.},
  author={Gerrie P. Farman and David Marcus Gore and Edward J. Allen and Kelly Q Schoenfelt and T. Irving and Pieter P. de Tombe},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2011},
  volume={300 6},
  pages={H2155-60}
}
The cellular mechanism underlying the Frank-Starling law of the heart is myofilament length-dependent activation. The mechanism(s) whereby sarcomeres detect changes in length and translate this into increased sensitivity to activating calcium has been elusive. Small-angle X-ray diffraction studies have revealed that the intact myofilament lattice undergoes numerous structural changes upon an increase in sarcomere length (SL): lattice spacing and the I(1,1)/I(1,0) intensity ratio decreases… CONTINUE READING