Myosin filament 3D structure in mammalian cardiac muscle☆

  title={Myosin filament 3D structure in mammalian cardiac muscle☆},
  author={Hind A. Al-Khayat and Edward Patrick Morris and Robert W. Kensler and John M. Squire},
  booktitle={Journal of structural biology},
A number of cardiac myopathies (e.g. familial hypertrophic cardiomyopathy and dilated cardiomyopathy) are linked to mutations in cardiac muscle myosin filament proteins, including myosin and myosin binding protein C (MyBP-C). To understand the myopathies it is necessary to know the normal 3D structure of these filaments. We have carried out 3D single particle analysis of electron micrograph images of negatively stained isolated myosin filaments from rabbit cardiac muscle. Single filament images… CONTINUE READING
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