Myosin binding protein C phosphorylation in normal, hypertrophic and failing human heart muscle.

  title={Myosin binding protein C phosphorylation in normal, hypertrophic and failing human heart muscle.},
  author={Adam Jacques and O'neal Copeland and Andrew E. Messer and Clare E. Gallon and Katie King and William J. McKenna and Victor T. Tsang and Steven Marston},
  journal={Journal of molecular and cellular cardiology},
  volume={45 2},
Phosphorylation of myosin binding protein C (MyBP-C) was investigated in intraventricular septum samples taken from patients with hypertrophic cardiomyopathy undergoing surgical septal myectomy. These samples were compared with donor heart muscle, as a well-characterised control tissue, and with end-stage failing heart muscle. MyBP-C was partly purified from myofibrils using a modification of the phosphate-EDTA extraction of Hartzell and Glass. MyBP-C was separated by SDS-PAGE and stained for… CONTINUE READING


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