Myosin binding protein-C: enigmatic regulator of cardiac contraction.

  title={Myosin binding protein-C: enigmatic regulator of cardiac contraction.},
  author={C. Elizabeth Oakley and Jean E Chamoun and Louise Jennifer Brown and Brett D. Hambly},
  journal={The international journal of biochemistry & cell biology},
  volume={39 12},
Myosin binding protein C (MyBPC) is a sarcomeric protein whose role in sarcomere structure and regulation of contraction is currently under investigation. It is a member of the immunoglobulin superfamily and is found in the C-zone of the A-band of the sarcomere. The elongated structure of MyBPC is composed of a series of immunoglobulin and fibronectin domains, with the C-terminal domains binding to the myosin thick filament and the N-terminal domains interacting with the myosin subfragment-2… CONTINUE READING


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