Myosin X regulates netrin receptors and functions in axonal path-finding

@article{Zhu2007MyosinXR,
  title={Myosin X regulates netrin receptors and functions in axonal path-finding},
  author={Xiao-Juan Zhu and Cheng-zhong Wang and Peng Dai and Yi Xie and Ning-Ning Song and Yu Liu and Quan-sheng Du and Lin Mei and Yu-Qiang Ding and Wen-Cheng Xiong},
  journal={Nature Cell Biology},
  year={2007},
  volume={9},
  pages={184-192}
}
Netrins regulate axon path-finding during development, but the underlying mechanisms are not well understood. Here, we provide evidence for the involvement of the unconventional myosin X (Myo X) in netrin-1 function. We find that Myo X interacts with the netrin receptor deleted in colorectal cancer (DCC) and neogenin, a DCC-related protein. Expression of Myo X redistributes DCC to the cell periphery or to the tips of neurites, whereas its silencing prevents DCC distribution in neurites… 

Myosin X Interaction with KIF13B, a Crucial Pathway for Netrin-1-Induced Axonal Development

TLDR
Netrin-1 increases Myosin X (Myo X) interaction with KIF13B, and thus promotes axonal delivery of Myo X and axon initiation and contralateral branching in developing cerebral neurons, revealing unrecognized functions and mechanisms underlying Netrin- 1 regulation of axon development.

Differential regulation of myosin X movements by its cargos, DCC and neogenin

TLDR
Different regulatory roles on Myo X activity by its cargo proteins, DCC and neogenin are demonstrated, revealing different cellular functions of D CC and neogensin.

p120RasGAP Protein Mediates Netrin-1 Protein-induced Cortical Axon Outgrowth and Guidance*

TLDR
A novel mechanism is provided that exploits the scaffolding properties of the N terminus of p120RasGAP to tightly regulate netrin-1/DCC-dependent axon outgrowth and guidance in embryonic cortical neurons.

Myosin X.

  • H. Tokuo
  • Biology
    Advances in experimental medicine and biology
  • 2020
TLDR
This chapter addresses the structure of the Myo10 gene; the molecular structure of Myosin X protein with its multiple domains; the regulation of actin structures induced in cells by Myo 10; the expression and function of Myo12 in vitro and in vivo; and the role of MyO10 in cancer.

Myo10 is required for neurogenic cell adhesion and migration

TLDR
It is found that knockdown of endogenous Myo10 in a normal gonadotropin-releasing hormone (GnRH) neuronal cell line transfected with the large T antigen (NLT) induced the impairment of cell motility and orientation, and N-cadherin, a calcium-dependent classical cell adhesion molecule, rescued the migration deficiency caused by Myo 10 knockdown in cell aggregates and collagen gel assay.

Myosin X and its motorless isoform differentially modulate dendritic spine development by regulating trafficking and retention of vasodilator-stimulated phosphoprotein

TLDR
This study demonstrates a novel biological function for Hdl-Myo10 and an important new role for both Myo10 isoforms in the development of dendritic spines and synapses in hippocampal neurons.

Myosin X regulates neuronal radial migration through interacting with N-cadherin

TLDR
A novel mechanism of Myo10 interacting with N-cadherin and regulating its cell-surface expression, which is required for neuronal adhesion and migration is revealed.

PtdIns (3,4,5) P3 Recruitment of Myo10 Is Essential for Axon Development

TLDR
Mechanism studies demonstrated that the recruitment of Myo10 through its PH domain to phosphatidylinositol (3,4,5)-trisphosphate (PtdIns) P3 was essential for axon formation and in vivo studies confirmed that Myo 10 was required for neuronal morphological transition during radial neuronal migration in the developmental neocortex.

Emerging roles for neogenin and its ligands in CNS development

TLDR
Neogenin is a multifunctional receptor regulating diverse developmental processes, and its contribution to neural development is proving to be considerably more extensive than originally predicted.

Myo10 is a key regulator of TNT formation in neuronal cells

TLDR
Results indicate that, in neuronal cells, TNTs can arise from a subset of Myo10-driven dorsal filopodia, independent of its binding to integrins and N-cadherins.
...

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