Myosin-X provides a motor-based link between integrins and the cytoskeleton

@article{Zhang2004MyosinXPA,
  title={Myosin-X provides a motor-based link between integrins and the cytoskeleton},
  author={Hongquan Zhang and Jonathan S Berg and Zhilun Li and Yunling Wang and Pernilla L{\aa}ng and Aurea D Sousa and Aparna Bhaskar and Richard E. Cheney and Staffan Str{\"o}mblad},
  journal={Nature Cell Biology},
  year={2004},
  volume={6},
  pages={523-531}
}
Unconventional myosins are actin-based motors with a growing number of attributed functions. Interestingly, it has been proposed that integrins are transported by unidentified myosins to facilitate cellular remodelling. Here we present an interaction between the unconventional myosin-X (Myo10) FERM (band 4.1/ezrin/radixin/moesin) domain and an NPXY motif within β-integrin cytoplasmic domains. Importantly, knock-down of Myo10 by short interfering RNA impaired integrin function in cell adhesion… CONTINUE READING
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